This seminal systematic review investigates the impact of youth employment interventions on the labour market outcomes of young people. The systematic review and meta-analysis is based on evidence from 113 counterfactual-based impact evaluations of 107 active labour market programs in 31 low-, middle- and high-income countries. It covers labor market programs in both agriculture and non-agriculture sectors. Overall, empirical results indicate that investing in young people through active labour market programmes pays off with positive impacts, particularly on employment and earnings outcomes. This impact does not take effect immediately and is more pronounced among low- and middle-income countries than among high-income countries. Moreover, the effects vary greatly between programmes’ type, design and context, indicating the need for careful design of youth employment interventions, and that the targeting of disadvantaged youth may act as a key factor for success.